Biosisto stands for Microbiological Control. Biosisto focuses on the production of microbiological reference material (RM), Certified Reference Materials (CRM) and tools used by food, dairy and water laboratories for quality control purposes. Certified reference materials should be of unquestionable quality to provide an effective process control. Quality control could effect the organization in a positive manner, using modern means.


Since January 2016, Biosisto has adopted the production and the delivery of reference material from the Dutch Government’s Food and Consumer Product Safety Authority (NVWA).  Biosisto has the ambition to be the authority in microbiological reference materials, where quality and reliability are very important! In the coming years Biosisto will substantially invest in her products and services and the following innovations:

  • In addition to the development of single strain reference materials Biosisto is to produce an increasing amount of multi-strain reference materials. Together with the customer, Biosisto will pursue the smartest combinations of micro-organisms to achieve a more efficient, effective application of the first-line control of your laboratory.
  • Biosisto is going to develop her products in a freeze-dried state. This makes Biosisto her reference material remaining stable at higher temperatures. This potentially saves transport costs and storage costs.
  • Another addition is the implementation of a web shop, which will be foreseen in the first half of 2016. The web shop will contain the correct personal information and functionality, allowing you to order products quickly and efficiently.

Annemarie Mulder, Maarten de Vries and André Siccama are the founders of Biosisto.


Annemarie has worked for the NVWA at Groningen for 30 years. Since 1997 Annemarie has devoted her time entirely to the production of microbiological reference materials. In the year 2008 the CHEK working group of the NVWA earned the P001 accreditation for the production of materials as the first producer of microbiological materials in the Netherlands. Annemarie is independent and motivated to deliver good work. She is practical, flexible and feels very responsible for her work, with priority to customer satisfaction and quality.


Maarten has 25 years’ experience in various IT functions. In the first years of his career he developed systems for internal chemical and microbiological laboratories. The last 10 years as an entrepreneur in internet application services. Maarten was from 2002 to 2012 together with two partners the owner and director of the IT company ApplicationNet b.v. which was sold to Royal KPN in 2012. ApplicationNet b.v. sold internet application services to large enterprise customers. Maarten is focused, enthusiastic, persistent and he is able to simplify things.


André has 18 years’ experience in various laboratory environments and functions. He has worked in hospital, pharmaceutical, food, non-food and dairy laboratories. The last years André was responsible for the development and introduction of improvement programs and performing Root Cause Analyses in situations of uncontrolled quality. André gets satisfaction in achieving results and in taking responsibility for those results. He believes that everything always can get better.